COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES AND CONDITIONS

摘要

The present invention relates to compositions and methods for prevention and treatment of ocular diseases and conditions, particularly glaucoma and ocular hypertension. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1-phosphate.

主权项

1. A method for treating, arresting the progression of, or preventing an ocular disease or disorder associated with undesirably high levels of sphingosine-1-phosphate (S1P), comprising delivering to an eye of a subject in need of such treatment an amount of a composition effective to treat or prevent the ocular disease or disorder, thereby treating, arresting the progression of, or preventing the ocular disease or disorder in said eye, wherein the composition comprises an antibody, or antibody fragment, that binds and neutralizes S1P.