发明名称 |
BISPECIFIC ANTIBODIES SPECIFIC FOR T-CELL ACTIVATING ANTIGENS AND A TUMOR ANTIGEN AND METHODS OF USE |
摘要 |
<p>The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.</p> |
申请公布号 |
EP2747781(A1) |
申请公布日期 |
2014.07.02 |
申请号 |
EP20120748490 |
申请日期 |
2012.08.21 |
申请人 |
ROCHE GLYCART AG |
发明人 |
BRUENKER, PETER;FAUTI, TANJA;JAEGER, CHRISTIANE;KLEIN, CHRISTIAN;UMANA, PABLO |
分类号 |
A61K39/395;A61P35/00;C07K16/30 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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