| 摘要 |
The present invention relates to methods for culturing and generation of mesodermal progenitor cells, more particularly methods to produce mesodermal progenitor cells, starting from pluripotent stem cells. The invention relates to methods for isolation of such cells by selecting them on the basis of the expression of marker genes such as CD44, CD140a and CD140b. The invention is also directed to the cells produced by the methods of the invention. The cells are useful, among other things, for treatment of disorders, diseases or injuries, such as conditions leading to deterioration of mesodermal derivative tissues (e.g. congenital myopathies, heart diseases and skeletal muscle diseases). |
