发明名称 |
A METHOD OF CHARACTERIZING ANTIBODIES |
摘要 |
<p>A method of characterizing a population of antibodies to an antigen comprises contacting a sensor surface having the antigen immobilized thereto with a sample containing the antibody population to bind antibodies to the surface, and detecting dissociation of antibodies from the sensor surface during a dissociation phase when sample no longer contacts the surface. Based on the dissociation behaviour, the antibody population is characterized in terms of subpopulations of more and less stable antibodies, respectively. The method may be used to determine the immunogenicity of drug by monitoring the appearance of anti-drug antibodies in a patient over time, and determining any shift in proportions between more stable and less stable antibodies.</p> |
申请公布号 |
EP2313777(B1) |
申请公布日期 |
2014.07.02 |
申请号 |
EP20090808459 |
申请日期 |
2009.08.17 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
ANDERSSON, KARL;KARLSSON, ROBERT |
分类号 |
G01N33/557;G01N21/55;G01N33/553 |
主分类号 |
G01N33/557 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|