发明名称 |
Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
摘要 |
A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer. |
申请公布号 |
US8765173(B2) |
申请公布日期 |
2014.07.01 |
申请号 |
US200812809259 |
申请日期 |
2008.12.18 |
申请人 |
Ardenia Investments, Ltd. |
发明人 |
Aleksov Julian;Lokot Igor |
分类号 |
A61K9/48 |
主分类号 |
A61K9/48 |
代理机构 |
Renner, Otto, Boisselle & Sklar, LLP |
代理人 |
Renner, Otto, Boisselle & Sklar, LLP |
主权项 |
1. A drug delivery system for administration of a pharmaceutically active substance that is a cationic amphiphile by itself and has a solubility per se in water of at least 4 mg/ml, wherein the drug delivery system comprises nanoparticles smaller than about 50 nm having a solubility in water below 0.1 mg/ml, said nanoparticles being formed by said substance in association with a sodium salt of the methyl ester of N-all-trans-retinoyl cysteic acid, a sodium salt of methyl ester of N-13-cis-retinoyl cysteic acid, or a combination thereof. |
地址 |
London, Greater London GB |