| 发明名称 | Methods and compositions involving miRNA and miRNA inhibitor molecules | ||
| 摘要 | The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays. | ||
| 申请公布号 | US8765709(B2) | 申请公布日期 | 2014.07.01 |
| 申请号 | US201314012302 | 申请日期 | 2013.08.28 |
| 申请人 | Asuragen, Inc. | 发明人 | Brown David;Ford Lance;Cheng Angie;Jarvis Rich;Byrom Mike;Ovcharenko Dmitriy;Devroe Eric;Kelnar Kevin |
| 分类号 | C12N15/11 | 主分类号 | C12N15/11 |
| 代理机构 | Nutter McClennen & Fish LLP | 代理人 | Nutter McClennen & Fish LLP ;Linnik Konstantin;Hubner Isaac A. |
| 主权项 | 1. A method of decreasing lung cancer or thyroid cancer cell proliferation, comprising providing to a lung cancer or thyroid cancer cell an effective amount of an miRNA inhibitor molecule between 15 and 130 nucleotide residues in length, having a sequence that is at least 90% complementary to the sequence of nucleotides 65-87 of SEQ ID NO:170, thereby decreasing lung cancer or thyroid cancer cell proliferation. | ||
| 地址 | Austin TX US | ||