Crystalline methylthioninium chloride hydrates

摘要

Three dihydrate forms B, C and D and a monohydrate form E of methylthioninium chloride are described. Forms B, C, D and E can be prepared under controlled humidity and temperature from methylthioninium chloride with higher water content or conversion of a hydrate. The hydrates can be incorporated in pharmaceutical compositions.

主权项

1. Crystalline methylthioninium chloride dihydrate as Form C, having the following characteristic peaks in a powder X-ray diffraction pattern:Peak2θ values (±0.1°)18.1211.1317.6425.9527.2.