摘要 |
The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc. |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
OSHIMA, KUNIO;OSHIYAMA, TAKASHI;TAIRA, SHINICHI;MENJO, YASUHIRO;YAMABE, HOKUTO;MATSUMURA, SHUUJI;UEDA, MASATAKA;KOGA, YASUO;TAI, KUNINORI;NAKAYAMA, SUNAO;ONOGAWA, TOSHIYUKI;TSUJIMAE, KENJI |