CONTROLLED-RELEASE FORMULATIONS FOR ORAL DOSAGE COMPRISING CORE LAYER AND ONE OR MORE BARRIER LAYERS

摘要

PROBLEM TO BE SOLVED: To provide: a controlled-release formulation that releases an active agent with an ascending release rate in response to the change in pH when it reaches gastrointestinal tract after its administration to a patient; a method of producing the same; and a method of using the same.SOLUTION: Solid controlled-release multilayer formulations for oral dosage contains: a core layer comprising one or more active agents and one or more enteric materials; and two or more barrier layers comprising one or more swellable, erodible, or gellable polymers, wherein the one of the barrier layers is provided on the upper side of the core layer and the other(s) thereof are/is provided on the lower side of the core layer.