| 摘要 |
<p>A cell culture device for culturing cells and measuring mechanical forces exerted by one or more cells. The device includes a cell culture chamber having a bottom plate and a main frame with side walls to enclose a volume. The main frame has side walls fabricated as one piece. The cell culture chamber is open on a side opposite the bottom plate. The device further has a force sensor array on top of the bottom plate within the cell culture chamber. The force sensor array has an array of flexible microcolumns configured to provide a site of adhesion for one or more cells, each microcolumn being configured to be deflected from an original position to a deflected position in response to a mechanical force exerted by the one or more cells.</p> |
