主权项 |
1. A composition for topical application of methylphenidate comprising methylphenidate in an adhesive carrier of a flexible, finite system, where the adhesive carrier consists of:
methylphenidate in an amount of 5 to 35 wt % methylphenidate, based on the total weight of the adhesive composition, effective to achieve substantially zero order kinetics for delivery to the skin or mucosa of a patient in need thereof over a period of at least 10 hours, and one or more non-functional or minimally functional acrylic polymers having no more than about 5 wt % of acid functional monomers, based on the weight of the acrylic polymer, and having no vinyl acetate monomers, and optionally, one or more excipients, tackifiers, plasticizers, and crosslinking agents. |