发明名称 |
PROCESS FOR THE PREPARATION OF TREPROSTINIL AND DERIVATIVES THEREOF |
摘要 |
A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position. |
申请公布号 |
WO2013174848(A3) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013EP60472 |
申请日期 |
2013.05.22 |
申请人 |
SCIPHARM SÀRL |
发明人 |
JAIN, NARESHKUMAR F.;KIRKUP, MICHAEL P.;MARELLA, MICHAEL A.;GHONE, SANJEEVANI, A. |
分类号 |
C07C67/29;C07C47/565;C07C47/575;C07C51/377;C07C59/72;C07C69/18;C07F7/18;C12P41/00 |
主分类号 |
C07C67/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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