TOPICAL USE OF VALPROIC ACID FOR THE PREVENTION OR TREATMENTOF SKIN DISORDERS

摘要

The present invention relates to a topically applicable formulation containi ng Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclea r receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre - malignant lesions, and of inflammations of the skin and/or mucosa. The invention also relates to the use of this topically applicable formulation f or the protection from UV light and for the treatment of sun burn. The inventio n includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.