发明名称 |
PREPARATION OF MAYTANSINOID ESTERS |
摘要 |
<p>Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods.</p> |
申请公布号 |
WO2014094354(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013CN01478 |
申请日期 |
2013.11.29 |
申请人 |
BIO-THERA SOLUTIONS, LTD. |
发明人 |
DENG, XIAOBIN |
分类号 |
C07D498/18;C07D498/08 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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