发明名称 |
AMIDE-BASED INSULIN PRODRUGS |
摘要 |
<p>Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.</p> |
申请公布号 |
EP2376521(A4) |
申请公布日期 |
2014.06.25 |
申请号 |
EP20090837985 |
申请日期 |
2009.12.18 |
申请人 |
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION |
发明人 |
DIMARCHI, RICHARD, D.;KOU, BINBIN;CHENG, SHUJIANG |
分类号 |
C07K1/00 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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