MULTILAYER PROTEIN FILMS, METHODS OF MAKING, AND DRUG DELIVERY DEVICES AND BIOMEDICAL IMPLANTS EMPLOYING THE FILMS

摘要

A multilayer protein film has a mass of greater than 0.5 μg/cm2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 μg/cm2 comprises contacting a substrate with a protein solution at a temperature of from about 30° C. to about 95° C., wherein a multilayer protein film having a mass of greater than 0.5 μg/cm2 is formed on the substrate.