| 主权项 |
1. A compound of formula (I):in which:
R1 represents
a hydrogen or halogen atom,an alkyl group optionally substituted with —COOR5,an alkenyl group optionally substituted with —COOR5,a —COOR5 or —CONR5R6 group,an —NR5COR6 or —NR5—SO2R6 group,or an aryl group or a heteroaryl group, said aryl or heteroaryl group being optionally substituted with one or more groups selected from: halogen atoms, alkyl groups, cycloalkyl groups, —COOR5, —CF3, —OCF3, —CN, —C(NH2)NOH, —OR5, —O-Alk-COOR5, —O-Alk-NR5R6, —O-Alk-NR7R8, -Alk-OR5, -Alk-COOR5, —CONR5R6, —CO—NR5—OR6, —CO—NR5—SO2R7, —CONR5-Alk-NR5R6, —CONR5-Alk-NR7R8, -Alk-NR5R6, —NR5R6, —NC(O)N(CH3)2, —CO-Alk, —CO(OAlk)nOH, COO-Alk-NR5R6, COO-Alk-NR7R8 and 5-membered heteroaryl groups, said heteroaryl groups being optionally substituted with one or more groups selected from halogen atoms and alkyl, —CF3, —CN, —COOR5, -Alk-OR5, -Alk-COOR5, —CONR5R6, —CONR7R8, —CO—NR5—OR6, —CO—NR5—SO2R6, —NR5R6 and -Alk-NR5R6 groups, or with a hydroxyl group or with an oxygen atom,
n is an integer ranging from 1 to 3,R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C) below: in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached and:
Ra represents a hydrogen atom or an alkyl, haloalkyl, -Alk-CF3, -Alk-COOR5, -Alk′-COOR5, -Alk-CONR5R6, -Alk′-CONR5R6, -Alk-CONR7R8, -Alk-NR5R6, -AlkCONR5—OR6, -Alk-NR7R8, -Alk-cycloalkyl, -Alk-O—R5, -Alk-S—R5, -Alk-CN, —OR5, -OAlkCOOR5, —NR5R6, —NR5—COOR6, -Alk-aryl, -Alk-O-aryl, -Alk-O-heteroaryl, -Alk-heteroaryl or heteroaryl group, where the aryl or heteroaryl group is optionally substituted with one or more halogen atoms and/or alkyl, cycloalkyl, —CF3, —OCF3, —O—R5 or —S—R5 groups,Ra′ represents a hydrogen atom or a linear, branched, cyclic or partially cyclic alkyl group, or an -Alk-OR5, -Alk-NR5R6 or -Alk-NR7R8 group, Ra being optionally substituted with one or more halogen atoms,Rb represents a hydrogen atom or an alkyl or -Alk-COOR5 group,Rb′ represents a hydrogen atom or an alkyl, haloalkyl, cycloalkyl, phenyl or -Alk-COOR5 group,Rc represents a hydrogen atom or an alkyl, —CN, —COOR5, —CO—NR5R6, —CONR7R8—CO—NR5-Alk-NR5R6, —CONR5-Alk-OR5, —CONR5SO2R5, -Alk-aryl or -Alk-heteroaryl group, where the aryl or heteroaryl group is optionally substituted with one or more halogen atoms and/or alkyl, cycloalkyl, —CF3, —OCF3, —O-alkyl or —S-alkyl groups,Rc′ represents a hydrogen atom or an alkyl group,Rc″ represents a hydrogen atom or an alkyl, alkenyl, haloalkyl, cycloalkyl, -Alk-NR5R6, -Alk-NR7R8, -Alk-OR5 or -Alk-SR5 group, R4, located on position 6, 7 or 8 of the imidazopyridine nucleus, represents:
a hydrogen atom,a —COOR5 group,a —CO—NR5-Alk-NR5R6 group,a —CO—NR5-Alk-NR7R8 group, ora —CO—NR5-Alk-OR6 group, R5 and R6, which may be identical or different, represent hydrogen atoms, haloalkyl groups or alkyl groups, cycloalkyl groups or an Ms group, R7 and R8, which may be identical or different, represent hydrogen atoms or alkyl or phenyl groups, or else R7 and R8 together form a 3- to 8-membered saturated ring which can optionally contain a heteroatom, Alk represents a linear or branched alkylene chain, and Alk′ represents a linear, branched, cyclic or partially cyclic alkylene chain, optionally in the form of a pharmaceutically acceptable salt thereof.
|
