Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA

摘要

The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample.

主权项

1. A composition comprising hyaluronic acid molecules cross-linked using biotin and streptavidin in molar excess to biotin to form a hyaluronic acid matrix, wherein the biotin is covalently attached to the hyaluronic acid molecules, and wherein the streptavidin is present in 100- to 10000-fold molar excess to the biotin.