Biomedical materials

摘要

The present invention provides a process for the preparation of a silicate and carbonate co-substituted calcium phosphate material. The process comprises the steps of: forming a silicon and optionally carbon-containing calcium phosphate precipitate by an aqueous precipitation method involving preparing an aqueous solution comprising phosphate ions, silicate ions, calcium ions and optionally carbonate ions, wherein the ratio of Ca/P and of Ca/(P+Si) in the solution is maintained above approximately 1.67; and heating the precipitate in an atmosphere comprising carbon and oxygen to form a silicate and carbonate co-substituted calcium phosphate material. The present invention also provides a synthetic carbonate and silicate co-substituted hydroxyapatite material, as well as a biomedical material.

主权项

1. A synthetic carbonate and silicate co-substituted hydroxyapatite material, wherein said material comprises from 0.5 to 2.86% by weight of silicon and from 3 to 13% by weight of carbonate ions and is essentially phase-pure with substantially no impurity phases of calcium oxide and/or tricalcium phosphate.