HEPARINAS DE BAIXO PESO MOLECULAR, COMPREENDENDO PELO MENOS UMA LIGAÇÃO COVALENTE COM A BIOTINA OU UM DERIVADO DA BIOTINA, O RESPECTIVO PROCESSO DE PREPARO E O RESPECTIVO USO

摘要

Heparin derivatives (I) comprising a low molecular weight heparin chain covalently linked to biotin are new. Independent claims are also included for: (1) a process for preparing (I); (2) use of avidin or streptavidin for neutralizing (I). - ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. - MECHANISM OF ACTION : Factor Xa inhibitor; Factor IIa inhibitor.