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1. A compound of structural formula I:or a pharmaceutically acceptable salt thereof; wherein
Ar is an aryl or heteroaryl, wherein the aryl or heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of:
—OC1-10 alkyl,—OC3-6 cycloalkyl,—O-heteroaryl,—O-aryl,aryl,aryl substituted with one to three halogen,aryl substituted with one to three C1-10 alkyl,heteroaryl,heteroaryl substituted with one to three halogen,heteroaryl substituted with one to three C1-10 alkyl,halogen,—CO2H,—C1-10 alkoxycarbonyl,—CN,—CF3,NH2pyrrolidone,cycloheteroalkyl,C1-10 alkyl,C3-6 cycloalkyl, andC3-6 cycloalkyl substituted with one to three C1-10 alkyl; X is O, NH or OCH2; R1 is SO2H, CONHC1-10 alkyl, —C1-10 alkoxycarbonyl, aroyl, heteroaroyl, aryl, heteroaryl, cycloalkyl or cycloheteroalkyl wherein the CONHC1-10 alkyl, —C1-10 alkoxycarbonyl, aroyl, heteroaroyl, aryl, heteroaryl, cycloalkyl or cycloheteroalkyl are optionally substituted with one or more substituents independently selected from the group consisting of:
—OH,—OC1-10 alkyl,—OC3-6 cycloalkyl,—O heteroaryl,—O aryl,aryl substituted with one to three halogen,aryl,aryl substituted with one to three C1-10 alkyl,heteroaryl,halogen,SO2C1-10 alkyl,SO2-aryl,SO2-aryl-C1-10 alkyl,—C(O)H,—C(O)C1-10 alkyl,—C(O)C3-6 cycloalkyl,—C(O) cycloalkyl,—C(O) heteroaryl,—C(O) aryl,—OC(O)H,—OC(O)C1-10 alkyl,—OC(O)C3-6 cycloalkyl,—OC(O) cycloalkyl,—OC(O) heteroaryl,—OC(O) aryl,—NH2,CONH—C1-10 alkyl-aryl,—CONH2,—CO2H,—C1-10 alkoxycarbonyl,—CO2C1-10 alkylaryl,—CN,—CF3,—OCF3,—OCHF2,cycloheteroalkyl,pyrrolidone,C1-10 alkyl-OH,C1-10 alkyl, andC3-6 cycloalkyl.
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