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1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
Z1 is S; Z2 is C; Z3 is CR11; Z4 is N; X, R1 and R11, together with the atoms to which they are bound, form a phenyl ring optionally substituted with 1, 2, 3 or 4 Rf substituents; R2 is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)Ra, C(O)ORa, C(O)NRbRc and SO2Ra; R3 and R4 are each independently selected from C1-6 alkyl; or alternatively, R3 and R4 together with the carbon atom to which they are bound form C3-8 cycloalkyl or C3-8 cycloalkenyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, ORa, OC(O)Ra, OC(O)ORa, NRbRc, C(O)Ra, C(O)ORa, C(O)NRbRc, S(O)Ra, SO2Ra, SO2NRbRc, C1-6 alkyl and C1-6 haloalkyl; R5 is selected from C6-10 aryl and 5-10 membered heteroaryl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, ORa, OC(O)Ra, OC(O)ORa, OC(O)NRbRc, NRbRc, NRdC(O)Ra, NRdC(O)ORa, NRdC(O)NRbRc, NRdC(O)C(O)NRbRc, NRdC(S)Ra, NRdC(S)ORa, NRdC(S)NRbRc, NRdC(NRe)NRbRc, NRdS(O)Ra, NRdSO2Ra, NRdSO2NRbRc, C(O)Ra, C(O)ORa, C(O)NRbRc, C(S)Ra, C(S)ORa, C(S)NRbRc, C(NRe)NRbRc, SRa, S(O)Ra, SO2Ra, SO2NRbRc, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl, and 5-10 membered heteroaryl, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 Rf substituents; R6 and R7, at each occurrence, are each independently selected from hydrogen, halogen and C1-6 alkyl; Ra, at each occurrence, is independently selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 Rf substituents; Rb and Rc, at each occurrence, are each independently selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl, 5-10 membered heteroaryl, C(O)Rg, C(O)ORg, C(O)NRiRj; and SO2Rg, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 Rf substituents; Rd, at each occurrence, is independently selected from hydrogen and C1-6 alkyl; Re, at each occurrence, is independently selected from hydrogen, CN, OH, C1-6 alkoxy, C1-6 alkyl and C1-6 haloalkyl; Rf, at each occurrence, is independently selected from halogen, CN, ORh, OC(O)Rh, OC(O)ORh, OC(O)NRiRj, NRiRj, NRdC(O)Rh, NRdC(O)ORh, NRdC(O)NRiRj, NRdC(O)C(O)NRiRj, NRdC(S)Rh, NRdC(S)ORh, NRdC(S)NRiRj, NRdC(NRe)NRiRj, NRdS(O)Rh, NRdSO2Rh, NRdSO2NRiRj, C(O)Rh, C(O)ORh, C(O)NRiRj, C(S)Rh, C(S)ORh, C(S)NRiRj, C(NRe)NRiRj, SRh, S(O)Rh, SO2Rh, SO2NRiRj, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 Rk substituents; or two Rf substituents bound to a single carbon atom, together with the carbon atom to which they are both bound, form a group selected from carbonyl, C3-8 cycloalkyl and 3-8 membered heterocycloalkyl; Rg, at each occurrence, is independently selected from C1-6 alkyl, C1-6 haloalkyl, phenyl, naphthyl, and C7-11 aralkyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, OH, C1-6 alkoxy, C1-6 alkyl and C1-6 haloalkyl; Rh, at each occurrence, is independently selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 Rk substituents; Ri and Rj, at each occurrence, are each independently selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl, 5-10 membered heteroaryl, C(O)Rg, and C(O)ORg, wherein each of the C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C6-10 aryl, C7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, OH, C1-6 alkoxy, C1-6 alkyl and C1-6 haloalkyl; Rk, at each occurrence, is independently selected from halogen, CN, OH, C1-6 alkoxy, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, NHC(O)C1-6 alkyl, NHC(O)C7-11 aralkyl, NHC(O)OC1-6 alkyl, NHC(O)OC7-11 aralkyl, OC(O)C1-6 alkyl, OC(O)C7-11 aralkyl, OC(O)OC1-6 alkyl, OC(O)OC7-11 aralkyl, C(O)C1-6 alkyl, C(O)C7-11 aralkyl, C(O)OC1-6 alkyl, C(O)OC7-11 aralkyl, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C7-11 aralkyl substituent is optionally substituted with 1, 2 or 3 substituents selected from OH, C1-6 alkoxy, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, NHC(O)C1-6 alkyl, NHC(O)C7-11 aralkyl, NHC(O)OC1-6 alkyl, and NHC(O)OC7-11 aralkyl; or two Rk substituents bound to a single carbon atom, together with the carbon atom to which they are both bound, form a carbonyl group; and m is 1.
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