发明名称 |
8-CARBAMOYL-2-(2,3-DISUBSTITUTED PYRID-6-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES |
摘要 |
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc. |
申请公布号 |
KR20140075793(A) |
申请公布日期 |
2014.06.19 |
申请号 |
KR20147012846 |
申请日期 |
2012.10.11 |
申请人 |
ABBVIE INC. |
发明人 |
WANG LE;DOHERTY GEORGE;WANG XILU;TAO ZHI FU;BRUNKO MILAN;KUNZER AARON R.;WENDT MICHAEL D.;SONG XIAOHONG;FREY ROBIN;HANSEN TODD M.;SULLIVAN GERARD M.;JUDD ANDREW;SOUERS ANDREW |
分类号 |
C07D401/14;A61K31/4427;A61P35/00;C07D403/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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地址 |
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