DIAGNOSTIC AND SAMPLE PREPARATION DEVICES AND METHODS

摘要

Contemplated methods and devices are drawn to preparation and analysis of analytes from biological samples. In a preferred embodiment the analytes are nucleic acids that are both released from biological compartment present in the sample and fragmented through the use of a voltage potential applied to a pair of electrodes. The nucleic acids thus prepared are subsequently characterized.

主权项

1. A method of analyzing a biological sample, the method comprising:
transferring the biological sample to an extraction zone, wherein the extraction zone comprises a pair of electrodes; and applying a first electrical signal to the pair of electrodes, such that a plurality of nucleic acids are released from the biological sample and fragmented within the extraction zone to produce a plurality of fragmented nucleic acids, wherein the plurality of fragmented nucleic acids have an average length in bases that is at least partially determined by the first electrical signal applied to the pair of electrodes.