METHOD FOR MASS PRODUCTION OF IMMUNOGLOBULIN Fc REGION HAVING INITIAL METHIONINE RESIDUES DELETED THEREFROM

摘要

PROBLEM TO BE SOLVED: To provide a method for the mass production of an immunoglobulin Fc region, free of initial methionine residues.SOLUTION: Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin hinge Fc region linked at the N-terminus thereof to an immunoglobulin Fc region via a peptide bond. Thus the monomeric or dimeric immunoglobulin Fc region, free of the initial methionine residues, is mass-produced.