NOVEL PEPTIDES THAT ENHANCE TIGHT JUNCTION PERMEABILITY

摘要

The present invention provides novel peptides that facilitate the opening of mammalian tight junctions, i.e. tight junction agonists. The present invention also provides methods for the treatment of disease by administering to a subject suffering from the disease a composition comprising a peptide tight junction agonist of the invention in combination with a therapeutically effective amount of an active agent.

主权项

1. A peptide tight junction agonist comprising the amino acid sequence of SEQ ID NO:1, with at least one amino acid substitution, deletion, or insertion, or at least one chemical modification, with respect to SEQ ID NO: 1.