| 摘要 |
PROBLEM TO BE SOLVED: To provide a polyacetal drug conjugate as a release system.SOLUTION: The present invention relates to the conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I), where each occurrence of M is independently a modifier having a molecular weight of 10 kDa or less; denotes direct or indirect attachment of M to linker L; and each occurrence of Lis independently an optionally substituted succinamide-containing linker, thereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is directly or indirectly attached to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for preparing the conjugates, and uses of the conjugates in the treatment of various disorder, including, but not limited to cancer. |
