发明名称 SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND THE USE THEREOF
摘要 The present application relates to novel substituted imidazopyridines and imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
申请公布号 US2014171434(A1) 申请公布日期 2014.06.19
申请号 US201214115870 申请日期 2012.05.02
申请人 Follmann Markus;Stasch Johannes-Peter;Redlich Gorden;Griebenow Nils;Lang Dieter;Wunder Frank;Li Volkhart Min-Jian 发明人 Follmann Markus;Stasch Johannes-Peter;Redlich Gorden;Griebenow Nils;Lang Dieter;Wunder Frank;Li Volkhart Min-Jian
分类号 C07D471/04;A61K31/519;A61K45/06;C07D487/04 主分类号 C07D471/04
代理机构 代理人
主权项 1. A compound of the formula (I) in which A is nitrogen or CR3, whereR3 is hydrogen, deuterium, halogen, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, cyclopropyl, cyclobutyl, hydroxy, phenyl or 5- or 6-membered heteroaryl, in which (C1-C4)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, cyclopropyl and cyclobutyl, L is a #-CR4AR4B—(CR5AR5B)p-## group where# is the attachment site to the carbonyl group,## is the point of attachment to the pyrimidine or triazine ring,p is a number 0, 1 or 2,R4A is hydrogen, fluorine, (C1-C4)-alkyl, hydroxy or amino, in which (C1-C4)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and amino,R4B is hydrogen, fluorine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C1-C4)-alkoxycarbonylamino, cyano, (C3-C7)-cycloalkyl, difluoromethoxy, trifluoromethoxy, phenyl or a group of the formula -Q-R8, in which (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, cyano, trifluoromethyl, (C3-C7)-cycloalkyl, hydroxy, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and amino,and in whichQ is a bond or (C1-C4)-alkanediyl,R8 is —(C═O)r—OR9, —(C═O)r—NR9R10, —C(═S)—NR9R10, —NR9—(C═O)—R12, —NR9—(C═O)—NR10R11, —NR9—SO2—NR10R11, —NR9—SO2—R12, —S(O)s—R12, —SO2—NR9R10, 4- to 7-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl, in whichr is the number 0 or 1,s is the number 0, 1 or 2,R9, R10 and R11 independently of one another are each hydrogen, (C1-C6)-alkyl, (C3-C8)-cycloalkyl, 4- to 7-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl,orR9 and IV° together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle, in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkyl amino and di-(C1-C6)-alkylamino,orR10 and R11 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle, in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkyl amino and di-(C1-C6)-alkylamino,R12 is (C1-C6)-alkyl or (C3-C7)-cycloalkyl,orR9 and R12 together with the atom(s) to which they are respectively attached form a 4- to 7-membered heterocycle, in which the 4- to 7-membered heterocycle for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of cyano, trifluoromethyl, (C1-C6)-alkyl, hydroxy, oxo, (C1-C6)-alkoxy, trifluoromethoxy, (C1-C6)-alkoxycarbonyl, amino, mono-(C1-C6)-alkyl amino and di-(C1-C6)-alkylamino,andin which 4- to 7-membered heterocyclyl, phenyl and 5- or 6-membered heteroaryl for their part may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, oxo, thioxo and (C1-C4)-alkoxy,andin which the aforementioned (C1-C4)-alkyl, (C1-C6)-alkyl, (C3-C8)-cycloalkyl and 4- to 7-membered heterocyclyl groups, unless stated otherwise, may each independently of one another additionally be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl, amino, phenyl, 4- to 7-membered heterocyclyl and 5- or 6-membered heteroaryl,orR4A and R4B together with the carbon atom to which they are bonded form a (C2-C4)-alkenyl group, an oxo group, a 3- to 6-membered carbocycle or a 4- to 7-membered heterocycle, in which the 3- to 6-membered carbocycle and the 4- to 7-membered heterocycle may be substituted by 1 or 2 substituents selected independently from the group of fluorine and (C1-C4)-alkyl,R5A is hydrogen, fluorine, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl or hydroxy,R5B is hydrogen, fluorine, (C1-C4)-alkyl or trifluoromethyl, M is CH or N, R1 is (C1-C6)-alkyl, (C3-C8)-cycloalkylmethyl, benzyl or 5- or 6-membered heteroarylmethyl, where (C1-C6)-alkyl is substituted by a substituent selected from the group consisting of difluoromethyl and trifluoromethyl,where (C1-C6)-alkyl may be substituted by 1 to 3 fluorine substituents,where (C3-C8)-cycloalkylmethyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, methyl and methoxy,where benzyl is substituted by 1 to 3 fluorine substituents,andwhere 5- and 6-membered heteroarylmethyl may be substituted by 1 or 2 fluorine substituents, R2 is hydrogen, cyano, halogen, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl or (C3-C7)-cycloalkyl, R6 is hydrogen, cyano, halogen, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl or (C3-C7)-cycloalkyl, R7 is hydrogen, cyano, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl or (C3-C7)-cycloalkyl, or a salt thereof.
地址 Koln DE