COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HEPATITIS C VIRUS INFECTION

摘要

A recombinant vesicular stomatitis virus (rVSV) immunogenic composition useful in the treatment or prophylaxis of Hepatitis C virus infection involves a selected, sequential, modified order of VSV genes, as well as a specific selection of HCV nonstructural proteins. Methods of treatment or prevention of a mammalian subject for HCV using the recombinant VSV include administration of only the rVSV immunogenic composition. Alternatively, a method for treating or preventing HCV infection can include administering to the mammalian subject an effective amount of a priming composition including a plasmid comprising a single open reading frame encoding selected HCV nonstructural proteins under the control of regulatory sequences directing expression thereof by the plasmid and a pharmaceutically acceptable diluent. The priming composition is administered before and/or after administration of the above-described immunogenic rVSV composition.