FUNGICIDE N-CYCLOALKYL-N-BIPHENYLMETHYL-CARBOXAMIDE DERIVATIVES

摘要

The present invention relates to N-cycloalkyl-N-biphenylmethyl-carboxamide derivatives of formula (I);;wherein A, Z1, Z2, Z3, X, n, Y and m represent various substituents, their process of preparation, preparation intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions

主权项

1. A compound of formula (I)wherein
A represents a carbo-linked, unsaturated or partially saturated, 5-membered heterocyclyl group that can be substituted by up to four groups R; Z1 represents a non-substituted C3-C7-cycloalkyl or a C3-C7-cycloalkyl substituted by up to 10 atoms or groups that can be the same or different and that can be selected in the list consisting of halogen atoms; cyano; C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxy; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylaminocarbonyl; di-C1-C8-alkylaminocarbonyl; Z2 and Z3, that can be the same or different, represent a hydrogen atom; C1-C8-alkyl; C2-C8-alkenyl; C2-C8-alkynyl; cyano; nitro; a halogen atom; C1-C8-alkoxy; C2 C8-alkenyloxy; C2-C8-alkynyloxy; C3-C7-cycloalkyl; C1-C8-alkylsulphenyl; amino; C1-C8-alkylamino; di-C1-C8-alkylamino; C1-C8-alkoxycarbonyl; C1-C8-alkylcarbamoyl; di-C1-C8-alkylcarbamoyl; N—C1-C8-alkyl-C1-C8alkoxycarbamoyl; or Z2 and Z3 together with the carbon atom to that they are linked can form a substituted or non substituted C3-C7-cycloalkyl; X and Y independently represent a halogen atom; nitro; cyano; isonitrile; hydroxyl; sulfanyl; amino; pentafluoro-λ6-sulfanyl; C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylamino; di-C1-C8-alkylamino; C1-C8-alkoxy; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxy-C1-C8-alkyl; C1-C8-alkoxy-C1-C8-alkoxy; C1-C8-alkylsulphanyl; C1-C8-halogenoalkylsulphanyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkenyl; C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkynyl; C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different C2-C8-alkenyloxy; C2-C8-halogenoalkenyloxy comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkynyloxy; C2-C8-halogenoalkynyloxy comprising up to 9 halogen atoms that can be the same or different; C3-C7-cycloalkyl; C3-C7-cycloalkyl-C1-C8-alkyl; C3-C7-cycloalkyl-C2-C8-alkenyl; C3-C7-cycloalkyl-C2-C8-alkynyl; C3-C7-halogenocycloalkyl comprising up to 9 halogen atoms that can be the same or different; C3-C7-cycloalkyl-C3-C7-cycloalkyl; C1-C8alkyl-C3-C7-cycloalkyl; C6-C14-bicycloalkyl; formyl; formyloxy; formylamino; carboxy; carbamoyl; N-hydroxycarbamoyl; carbamate; (hydroxyimino)-C1-C8-alkyl; C1-C8alkylcarbonyl; C1-C8-halogenoalkylcarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8alkylcarbamoyl; di-C1-C8-alkylcarbamoyl; N—C1-C8-alkyloxycarbamoyl; C1-C8-alkoxycarbamoyl; N—C1-C8alkyl-C1-C8-alkoxycarbamoyl; C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylaminocarbonyl; di-C1-C8-alkylaminocarbonyl; C1-C8-alkylcarbonyloxy; C1-C8-halogenoalkylcarbonyloxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylcarbonylamino; C1-C8-halogenoalkylcarbonylamino comprising up to 9 halogen atoms that can be the same or different; C1-C8alkylaminocarbonyloxy; di-C1-C8-alkylaminocarbonyloxy; C1-C8alkyloxycarbonyloxy, C1-C8-alkylsulphenyl; C1-C8-halogenoalkylsulphenyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylsulphinyl; C1-C8-halogenoalkylsulphinyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylsulphonyl; C1-C8-halogenoalkylsulphonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxyimino; (C1-C8alkoxyimino)-C1-C8-alkyl; (C2-C8 alkenyloxyimino)-C1-C8-alkyl; (C2-C8-alkynyloxyimino)-C1-C8-alkyl; (benzyloxyimino)-C1-C8-alkyl; tri(C1-C8alkyl)silyl; tri(C1-C8-alkyl)silyl-C1-C8-alkyl; benzyloxy that can be substituted by up to 5 groups Q; benzylsulfanyl that can be substituted by up to 5 groups Q; benzylamino that can be substituted by up to 5 groups Q; aryl that can be substituted by up to 5 groups Q; aryloxy that can be substituted by up to 5 groups Q; arylamino that can be substituted by up to 5 groups Q; arylsulfanyl that can be substituted by up to 5 groups Q; aryl-C1-C8-alkyl that can be substituted by up to 5 groups Q; aryl-C2-C8-alkenyl that can be substituted by up to 5 groups Q; aryl-C2-C8-alkynyl that can be substituted by up to 5 groups Q; aryl-C3-C7-cycloalkyl that can be substituted by up to 5 groups Q; pyridinyl that can be substituted by up to 4 groups Q and pyridinyloxy that can be substituted by up to 4 groups Q; or two substituents X together with the consecutive carbon atoms to that they are linked can form a 5- or 6-membered, saturated, carbo- or hetero-cycle comprising up to 3 heteroatoms fused with the phenyl ring to that the two substituent X are linked, that can be substituted by up to 4 groups Q that can be the same or different; or two substituents Y together with the consecutive carbon atoms to that they are linked can form a 5- or 6-membered, saturated, carbo- or hetero-cycle comprising up to 3 heteroatoms fused with the phenyl ring to that the two substituent X are linked, that can be substituted by up to 4 groups Q that can be the same or different; n represents 0, 1, 2, 3 or 4; m represents 0, 1, 2, 3, 4 or 5; R independently represents a hydrogen atom; halogen atom; cyano; isonitrile; nitro; amino; sulfanyl; pentafluoro-λ6-sulfanyl; C1-C8-alkylamino; di-C1-C8-alkylamino; tri(C1-C8alkyl)silyl; C1-C8alkylsulfanyl; C1-C8-halogenoalkylsulfanyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkenyl; C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-alkynyl; C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxy; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C2 C8-alkenyloxy; C2-C8-alkynyloxy; C3-C7-cycloalkyl; C3-C7-cycloalkyl-C1-C8-alkyl; C1-C8-alkylsulphinyl; C1-C8-alkylsulphonyl; C1-C8alkoxyimino; (C1-C8-alkoxyimino)-C1-C8-alkyl; (benzyloxyimino)-C1-C8-alkyl; aryloxy; benzyloxy; benzylsulfanyl; benzylamino; aryl; halogenoaryloxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-alkylaminocarbonyl; di-C1-C8-alkylaminocarbonyl; Q independently represents a halogen atom; cyano; isonitrile; nitro; C1-C8-alkyl; C2-C8-alkenyl; C2-C8-alkynyl; C1-C8-alkoxy; C1-C8-alkoxy-C1-C8-alkyl; C1-C8-alkoxy-C1-C8-alkoxy; C1-C8-alkylsulphanyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-halogenoalkenyl comprising up to 9 halogen atoms that can be the same or different; C2-C8-halogenoalkynyl comprising up to 9 halogen atoms that can be the same or different; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; C1-C8-halogenoalkoxy-C1-C8-alkyl comprising up to 9 halogen atoms that can be the same or different; tri(C1-C8)alkylsilyl and tri(C1-C8)alkylsilyl-C1-C8-alkyl;as well as salts, N-oxides, metallic complexes, metalloidic complexes and optically active or geometric isomers thereof; with the exclusion of N-cyclopropyl-N-[(6-methoxybiphenyl-3-yl)methyl]isoxazole-5-carboxamide.