发明名称 |
HISTONE PROTEIN UBIQUITINATION AS A CANCER BIOMARKER |
摘要 |
The present disclosure relates generally to the field of cancer diagnosis. More specifically, the present disclosure relates to the identification and use of monoubiquitination of histone 2B as a biomarker for the diagnosis and prognosis of cancer including, but not limited to, parathyroid cancer. The present disclosure also relates to the identification of binding between CDC73 and RNF20, and the use of CDC73 and RNF20 in an assay for screening for an agent that modulates monoubiquitination of a histone protein. |
申请公布号 |
EP2638394(A4) |
申请公布日期 |
2014.06.18 |
申请号 |
EP20110839316 |
申请日期 |
2011.11.14 |
申请人 |
NORTHERN SYDNEY LOCAL HEALTH DISTRICT |
发明人 |
MARSH, DEBORAH JOY;HAHN, MICHAEL ANTHONY |
分类号 |
G01N33/53;C07K16/18;C07K16/30;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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