发明名称 |
METHODS FOR REVERTING METHYLATION BY TARGETING DNMT3A AND DNMT3B |
摘要 |
<p>Methods for restoring a desired pattern of DNA methylation, inducing re-expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed.</p> |
申请公布号 |
EP2173911(B1) |
申请公布日期 |
2014.06.18 |
申请号 |
EP20080796821 |
申请日期 |
2008.07.30 |
申请人 |
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
CROCE, CARLO, M.;FABBRI, MULLER |
分类号 |
C12Q1/68;A61K31/7088 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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