Method for staging cancer progression by AFM

摘要

The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumor, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 μm and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumor tissue biopsy sample.

主权项

1. A method for classifying a tissue biopsy sample obtained from a tumour, comprising
determining, by a scanning probe microscope, the stiffness values for a plurality of points on said sample with a spatial resolution of at least 100 μm, resulting in a stiffness distribution, and classifying assigning said sample according to the determined stiffness values,wherein
a sample showing an at least bimodal stiffness distribution is classified as a malignant tumour, wherein said at least bimodal stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak.