发明名称 |
Pharmaceutical compositions having desirable bioavailability |
摘要 |
The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil. |
申请公布号 |
US8754123(B2) |
申请公布日期 |
2014.06.17 |
申请号 |
US201213442475 |
申请日期 |
2012.04.09 |
申请人 |
Alcon Research, Ltd. |
发明人 |
Kabra Bhagwati P. |
分类号 |
A01N37/08;A61K31/215;A61K9/00;A61K31/5575;A61K47/44 |
主分类号 |
A01N37/08 |
代理机构 |
|
代理人 |
Chapple Scott A. |
主权项 |
1. An aqueous ophthalmic pharmaceutical solution composition suitable for topical application to an eye of a human, comprising:
a prostaglandin suitable for lowering intraocular pressure of the eye, the prostaglandin being in the composition at a concentration that is at least 0.001 w/v % but less than 0.01 w/v %; a surfactant in the composition at a concentration that is at least 0.03 w/v % but less than 0.3 w/v %, wherein: i. the surfactant is entirely ethoxylated and/or hydrogenated vegetable oil and the ethoxylated and/or hydrogenated castor oil is the only surfactant in the composition; and ii. the composition is free of benzalkonium chloride; and a polymeric quaternary ammonium compound in the composition at a concentration that is greater than 0.0003 w/v % but less than 0.003 w/v %; and water.
|
地址 |
Fort Worth TX US |