Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis

摘要

The present invention relates to new salts of 6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol (rotigotine), their use as a medicament, for example for the treatment of CNS disorders like Parkinson Disease, RLS, fybromyalgia and/or depression, in particular through electromotive administration. The present invention relates to pharmaceutical formulations suitable for iontophoresis that provide enhanced iontophoretic delivery of rotigotine to at least one target tissue. The formulations are further characterized by good to excellent solubility of the salts in aqueous solutions.

主权项

1. A compound corresponding in structure to Formula I: wherein Xn− is an acid anion of a pharmaceutically acceptable inorganic or organic acid selected from the group consisting of hydrogen phosphate, dihydrogen phosphate, dihydrogen citrate, hydrogen citrate, orotate, 1-hydroxy-2-naphtoate, sulphate and hydrogen tartrate.