Imaging probes, methods of making imaging probes, and methods of imaging

摘要

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject or sample, methods of diagnosing the presence of one or more angiogenesis related diseases or related biological events in a subject or sample, method of monitoring the progress of one or more angiogenesis related diseases or related biological events in a subject or sample, a 18F-FBEM-CYS-ZEGFR:1907 probe, compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe, and pharmaceutical compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe and the like.

主权项

1. A method of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject, comprising:
administering to the subject a 18F-FBEM-CYS-ZEGFR:1907 probe, wherein 18F-FBEM is N-2-(4-18F-fluorobenzamido)ethyl-maleimide), wherein ZEGFR:1907 is SEQ ID NO: 1, and CYS is cysteine; imaging at least a portion of the subject; and detecting the 18F-FBEM-CYS-ZEGFR:1907 probe, wherein the location of the 18F-FBEM-CYS-ZEGFR:1907 probe corresponds to the over-expression of the EGFR.