| 发明名称 | Use of inhibitors of bruton's tyrosine kinase (Btk) | ||
| 摘要 | Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile. | ||
| 申请公布号 | US8754090(B2) | 申请公布日期 | 2014.06.17 |
| 申请号 | US201113340522 | 申请日期 | 2011.12.29 |
| 申请人 | Pharmacyclics, Inc. | 发明人 | Buggy Joseph J.;Fyfe Gwen;Loury David J. |
| 分类号 | A61K31/519;A61P35/00;A61P29/00;A61P35/02;C07D487/04 | 主分类号 | A61K31/519 |
| 代理机构 | Wilson, Sonsini, Goodrich & Rosati | 代理人 | Wilson, Sonsini, Goodrich & Rosati |
| 主权项 | 1. A method for treating mantle cell lymphoma in an individual who has already received at least one prior therapy for mantle cell lymphoma comprising administering to the individual once per day between about 420 mg to about 840 mg of an oral dose of an inhibitor of Bruton's tyrosine kinase (Btk) having the structure: | ||
| 地址 | Sunnyvale CA US | ||