发明名称 |
MUTATIONS IN THE EPIDERMAL GROWTH FACTOR RECEPTOR GENE |
摘要 |
The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comprising cetuximab and the sensitivity to a therapy regimen comprising panitumumab. The invention includes peptide sequences, primers and probes to detect such a mutation, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab and/or panitumumab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer and to head and neck cancer. |
申请公布号 |
KR20140072035(A) |
申请公布日期 |
2014.06.12 |
申请号 |
KR20147005437 |
申请日期 |
2012.08.02 |
申请人 |
FUNDACIO INSTITUT MAR D'INVESTIGACIONS MEDIQUES (IMIM) |
发明人 |
MONTAGUT VILADOT CLARA;ALBANELL MESTRES JOAN;ROVIRA GUERIN ANA;BELLOSILLO PARICIO BEATRIZ;DALMASES MASSEGU ALBA |
分类号 |
C07K7/06;C07K14/71;C12N15/11;C12Q1/68 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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