| 发明名称 |
NOVEL LIPIDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS |
| 摘要 |
The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery. |
| 申请公布号 |
US2014162962(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
US201414178538 |
申请日期 |
2014.02.12 |
| 申请人 |
AXOLABS GMBH |
发明人 |
CONSTIEN Rainer;Geick Anke;Hadwiger Philipp;Haneke Torsten;Ickenstein Ludger Markus;Hernandez Prata Carla Alexandra;Schuster Andrea;Weide Timo |
| 分类号 |
A61K47/22;A61K38/02;C07D295/30;A61K31/7088;A61K31/575;A61K31/713;C07D241/04;A61K31/70 |
主分类号 |
A61K47/22 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A cyclic amino-lipid of the formula: wherein: R1 is independently selected from
—(CH2)2—N(R)2,—(CH2)2—N(R)—(CH2)2—N(R)2, wherein R is independently selected from —H, C6-40 alkyl, C6-40 alkenyl and C6-40 alkynyl, provided that —N(R)2 is not NH2, C6-40 alkyl, and C6-40 alkenyl; R2 is C6-40 alkyl, C6-40 alkenyl or C6-40 alkynyl; and m is 0 or 1.
|
| 地址 |
Kulmbach DE |
