| 发明名称 |
BIOMARKER-TARGETING CONTRAST AGENTS AND THEIR USE IN MAGNETIC RESONANCE IMAGING FOR DETECTION OF ATHEROSCLEROTIC PLAQUE |
| 摘要 |
A composition comprising: a liposome having a bilayer structure, a gadofullerene having a high relaxivity, and an amphiphilic receptor ligand. In the composition, the gadofullerene is embedded in the bilayer structure of the liposome. In addition, a method for detecting atherosclerotic plaque in an animal using the composition is described. |
| 申请公布号 |
US2014161733(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
US201214007649 |
申请日期 |
2012.03.29 |
| 申请人 |
LUNA INNOVATIONS INCORPORATED |
发明人 |
Zhou Zhiguo;Lenk Robert P.;Kepley Christopher L. |
| 分类号 |
A61K49/18;A61K45/00 |
主分类号 |
A61K49/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising:
a drug delivery system composed of amphiphilic building blocks, a gadofullerene functionalized with an amine having a C4-C100 alkyl chain and an amine having an alkoxyalkyl chain, and a receptor ligand; wherein the gadofullerene is incorporated in the drug delivery system.
|
| 地址 |
Roanoke VA US |
