DIBENZOOXEPIN DERIVATIVE

摘要

A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPARγ agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.;

主权项

1. A tricyclic compound represented by the general formula (I) [wherein Y is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkoxy optionally having substituent(s), cycloalkyl optionally having substituent(s) or halogen, RA is a hydrogen atom, halogen, hydroxy, lower alkoxy, or lower alkyl, X is the formula (b1)-(b16) (wherein RB-2 is lower alkyl optionally having substituent(s) or cycloalkyl optionally having substituent(s), RB is a hydrogen atom, lower alkyl optionally having substituent(s) or cycloalkyl optionally having substituent(s), and the broken line shows absent or a single bond), A is the formula (a1)-(a29) (wherein R1, R2 and R3 are the same or different and each is a hydrogen atom, cyano, lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), halogen, lower alkoxy optionally having substituent(s), —NRFRG (wherein RF and RG are the same or different and each is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s) or aralkyl optionally having substituent(s), or RF and RG form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group optionally having substituent(s)), lower alkylsulfanyl optionally having substituent(s), lower alkenyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), carbamoyl, lower alkylcarbamoyl optionally having substituent(s), di-lower alkylcarbamoyl optionally having substituent(s), aliphatic heterocyclylcarbonyl optionally having substituent(s), aryloxy optionally having substituent(s), aryl optionally having substituent(s), aromatic heterocyclic group optionally having substituent(s), aliphatic heterocyclic group optionally having substituent(s), aralkyl optionally having substituent(s) or aralkyloxy optionally having substituent(s), RC, RD and RE are the same or different and each is a hydrogen atom, halogen, nitro, cyano, formyl, oxo, hydroxy, lower alkoxy optionally having substituent(s), —NRFaRGa (wherein RFa and RGa are as defined for the aforementioned RF and RG, respectively), lower alkanoyloxy optionally having substituent(s), lower alkyl optionally having substituent(s), lower alkenyl optionally having substituent(s), lower alkynyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), lower alkylsulfonyl optionally having substituent(s), lower alkylsulfanyl optionally having substituent(s), cycloalkyl optionally having substituent(s) or —CONRHRO (wherein RH and RI are the same or different and each is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s) or aralkyl optionally having substituent(s), or RH and RI form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group optionally having substituent(s)), RJ is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), aryl optionally having substituent(s), lower alkylsulfonyl optionally having substituent(s), aralkyl optionally having substituent(s) or cycloalkyl optionally having substituent(s), and RK is a hydrogen atom, halogen, hydroxy, lower alkoxy, lower alkyl or —NRFbRGb (wherein RFb and RGb are as defined for the aforementioned RF and RG, respectively)], or a pharmaceutically acceptable salt thereof.