METHODS FOR TREATING 5-FLUOROURACIL PRODRUG NON-RESPONSIVE CANCER PATIENTS

摘要

Methods for treating a patient who had rapid disease progression on a 5-FU prodrug regimen comprising first administering to the patient a DPD inhibitor that substantially eliminates activity of the enzyme in both nervous and non-nervous tissues within the patient and thereafter administering 5-FU, wherein the level of 5- FU is in substantial excess of DPD inhibitor in the patient are envisioned. Also encompassed herein are a DPD inhibitor for use in a combined treatment with 5-FU, a combination for treating a patient having rapid disease progression on a 5-FU prodrug regimen comprising a DPD inhibitor and 5-FU, and use of eniluracil in combination with 5-FU for the manufacture of a medicament for treating a patient having rapid disease progression on a 5-FU prodrug regimen.