| 发明名称 |
Vaccine for shigella |
| 摘要 |
Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an Shigella sonnei infection. The disclosed immunogenic conjugates have the general structure:
Pr—Sr—O—N═C-Kdo-OS
wherein Pr is a carrier protein, Sr is an optional spacer moiety, Kdo is an 3-deoxy-D-manno-octulosonic acid or a derivative thereof, and OS is an oligosaccharide or polysaccharide obtained from S. sonnei. In specific examples, the immunogenic conjugates include the core oligosaccharide obtained from S. sonnei having the structure:
;wherein R is between 1 and 10 disaccharide repeat units.;In specific examples, the disaccharide repeat unit included in the immunogenic conjugate has the structure:
α-L-AltNAcA-3-β-FucNAc4N-4-. |
| 申请公布号 |
US8747863(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US200913059051 |
申请日期 |
2009.08.14 |
| 申请人 |
The United States of America, as represented by the Secretary of the Department of Health and Human Services;National Research Council of Canada |
发明人 |
Robbins John B.;Schneerson Rachel;Kubler-Kielb Joanna;Mocca Christopher P.;Vinogradov Evguenii |
| 分类号 |
A61K49/00;A61K39/00;A61K47/00;A61K39/02;A61K39/385;A61K47/06 |
主分类号 |
A61K49/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunogenic conjugate comprising the structure of:
Pr—Sr—O—N═C-Kdo-OSwherein Pr is a carrier protein, Sr is an optional spacer moiety, Kdo is 3-deoxy-D-manno-octulosonic acid, and OS comprises at least one oligosaccharide or polysaccharide obtained from S. sonnei.
|
| 地址 |
Washington DC US |
