发明名称 |
MATERIALS AND METHODS USEFUL TO TREAT NEUROBLASTOMAS AND PHEOCHROMOCYTOMAS |
摘要 |
Methods for affecting one or more of: proliferation, migration and invasion of tumor cells are described. One method includes contacting the tumor cell with an effective amount of a composition such as tianeptine. Described herein are results showing that tianeptine causes apoptosis by increasing microtubule bundling in neuroblastoma and pheochromocytoma cells. In addition, tianeptine blocks growth of neuroblastoma and pheochromocytoma by inducing specific and rapid degradation of cytoplasmic dynein, a microtubule motor protein that arranges the mitotic spindles during mitosis. |
申请公布号 |
WO2014059279(A3) |
申请公布日期 |
2014.06.05 |
申请号 |
WO2013US64546 |
申请日期 |
2013.10.11 |
申请人 |
THE UNIVERSITY OF TOLEDO |
发明人 |
PARK, JOSHUA, J.;HENSLEY, KENNETH |
分类号 |
A61K31/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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