WATER-SOLUBLE CAMPTOTHECIN DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF

摘要

The present invention relates to a water soluble derivative of camptothecin and preparation method thereof, the derivative having a structure of formula I and being appropriate in water solubility, and having anti-cancer activity and stability of lactonic ring. The present invention also relates to a method for synthesizing the compound and medical use of the compound.;

主权项

1. A water-soluble camptothecin derivative, comprising
a compound of Formula I and pharmaceutically acceptable salts thereof: wherein M represents hydroxyl or thiol, A represents ribose or deoxyribose or ribose derivative and is attached to a phosphorus atom via an oxygen of an hydroxyl group