Bonding tissues and cross-linking proteins with naphthalimide compounds

摘要

Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

主权项

1. A method for local delivery of a functional compound to skin comprising:
contacting a compound having the formula D-B—F to skin; and subjecting the compound to an activating agent wherein the compound is cleaved so that a compound B—F is tethered to the skin; and wherein D is a naphthalimide compound having the following formula: which is a mixture of stereoisomers, wherein n is an integer from about 1 to about 20; R is selected from the group consisting of CH3, C4H9, C6H13, (CH2)2N(CH3)3+, CH2COOH, (CH)2CH2(CH3)2COOH, and (CH)2CH2(CH3)2COOCH3; and R* is a bond between D and B, B is a biomolecule selected from the group consisting of chitosan, protein, hydrolyzed protein, and carbohydrates, and F is the functional compound comprising at least one of sulfonic acid functional groups, alcohol functional groups, and amine functional groups.