发明名称 Preparation of erythropoietin by endogenous gene activation
摘要 The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.
申请公布号 US6544748(B2) 申请公布日期 2003.04.08
申请号 US20010985357 申请日期 2001.11.02
申请人 ROCHE DIAGNOSTICS GMBH 发明人 STERN ANNE;BRANDT MICHAEL;HONOLD KONRAD;AUER JOHANNES;KOLL HANS
分类号 A61K38/00;C07K14/505;C12N5/08;C12N15/10;C12N15/62;C12P21/00;C12P21/04;(IPC1-7):C12Q1/68;C12P21/06;C12N15/64;C12N15/00;C12N15/09 主分类号 A61K38/00
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