Anti-diabetic compounds

摘要

The preset invention relates to a new oral anti-diabetic compound prepared by synthesizing a steroid and a guanide or biguanide, which is eliminated via the hepatic route, instead of the renal route, to avoid adverse effects of administering metformin in diabetic patients with renal dysfunction. A pharmaceutical composition comprising the compound of the invention and the method for treating diabetes using the compound are also provided.

主权项

1. A compound having the structure of Formula Ia or Ib wherein R4 and R7 are independently hydrogen, hydroxyl, methoxyl, ethoxyl, ═O, —O-acetyl, or —O-benzoyl; R17 is hydroxyl, methoxyl, ethoxyl, or one amino group selected from those of the following formulas:  and R12 is a guanide or biguanide having the following formula: wherein R13 and R14 are independently selected from hydrogen, methyl, n-butyl, or phenethyl.