发明名称 |
Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
摘要 |
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. |
申请公布号 |
US8741904(B2) |
申请公布日期 |
2014.06.03 |
申请号 |
US201313950642 |
申请日期 |
2013.07.25 |
申请人 |
Alfa Wassermann S.p.A. |
发明人 |
Viscomi Giuseppe Claudio;Campana Manuela;Confortini Donatella;Barbanti Maria;Braga Dario |
分类号 |
C07D498/22;A61K31/395 |
主分类号 |
C07D498/22 |
代理机构 |
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代理人 |
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主权项 |
1. Rifaximin in polymorphic form δ, wherein the rifaximin polymorphic form δ has x-ray powder diffraction pattern peaks at about 5.7°±0.2, 12.1°±0.2, and 17.0°±0.2 2-θ.
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地址 |
IT |