| 摘要 |
599204 Disclosed is an isolated human antibody or antigen-binding fragment thereof that specifically binds to human PAR-2 (SEQ ID NO:851), wherein the antibody or antigen-binding fragment thereof: (a) interacts with Ser-37, Leu-38, Ile-39, Gly-40, Val-42 and Asp-43 of human PAR-2; (b) does not interact with Lys-41 of human PAR-2; (c) blocks trypsin cleavage of human PAR-2 at the activating cleavage site located at the junction of residues Arg-36 and Ser-37 of human PAR-2; (d) does not block trypsin cleavage of human PAR-2 at the non-activating cleavage site located at the junction of residues Arg-31 and Ser-32; and (e) competes for binding to human PAR-2 with a reference antibody comprising heavy chain complimentary determining regions (HCDR1-HCDR2-HCDR3) having the amino acid sequences of SEQ ID NOs:700-702-704; and the light chain CDRs (LCDR1-LCDR2-LCDR3) having the amino acid sequences of SEQ ID NOs:708-710-712. |
